The APLF Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to APLF. This antibody recognizes Human, and Mouse antigen. The APLF Polyclonal Antibody has been shown to work in the following applications: Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
Nuclease involved in single-strand and double-strand DNA break repair (PubMed:17396150). Recruited to sites of DNA damage through interaction with poly (ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions (PubMed:17396150, PubMed:21211721). Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage (PubMed:17396150). Together with PARP3, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ)(PubMed:21211721)