MyBioSource.com's Rabbit Anti-Histone H2A.X Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Other. The Rabbit Anti-Histone H2A.X Antibody was generated using H2A.X variant histone, and H2AX as the antigen and it reacts with Human.
Description
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation