The HMGB1 Rabbit pAb Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to HMGB1. This antibody recognizes Human, Mouse, and Rat antigen. The HMGB1 Rabbit pAb Antibody has been shown to work in the following applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Western Blot.
Description
High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, members of the NFkappaB family, ATF-2 and c-Jun to activate transcription