The [KO Validated] ARMET/ARP/MANF Rabbit pAb Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to PAK5. This antibody recognizes Human, Mouse, and Rat antigen. The [KO Validated] ARMET/ARP/MANF Rabbit pAb Antibody has been shown to work in the following applications: Immunocytochemistry, Immunofluorescence, and Western Blot.
Description
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related