The Rabbit Anti-BLNK Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to B cell linker, and BLNK. This antibody recognizes Human, Mouse, and Rat antigen. The Rabbit Anti-BLNK Antibody has been shown to work in the following applications: Immunofluorescence.
Description
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]