MyBioSource.com's Rabbit Anti-IP3R-I Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot. The Rabbit Anti-IP3R-I Antibody was generated using ITPR1 as the antigen and it reacts with Human, Mouse, and Rat.
Description
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1, 4, 5- trisphosphate (PubMed:27108797). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity)