MyBioSource.com's [KO Validated] BUB1 Rabbit pAb is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Western Blot. The [KO Validated] BUB1 Rabbit pAb Antibody was generated using BUB1, and TWF2 as the antigen and it reacts with Human, Mouse, and Rat.
Description
This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants