The NEDD8 Activating Enzyme E1C Rabbit mAb Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to UBA3. This antibody recognizes Human, Mouse, and Rat antigen. The NEDD8 Activating Enzyme E1C Rabbit mAb Antibody has been shown to work in the following applications: Western Blot.
Description
Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression