The Patched Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to PTCH1. This antibody recognizes Human, and Mouse antigen. The Patched Polyclonal Antibody has been shown to work in the following applications: Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis