MyBioSource.com's Anti-Hu CD33 PerCP is a Mouse monoclonal antibody. The Anti-Hu CD33 PerCP Antibody was generated using CD33 as the antigen. It reacts with Human, and Non-Human Primate. This antibody has been shown to work in applications such as: Flow Cytometry.
Description
CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia