MyBioSource.com's Rabbit Anti-OATP3 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: EIA, Immunoassay, ELISA, and Western Blot.
Description
Mammalian kidney and liver are critical in maintaining physiological ionic environment. Kidney specializes in removing toxins, drugs, and other organic anions from the blood by a process called "renal secretion". Besides kidney, anionic substrates are also transported in other organs, e.g., choroid plexus, eye, airway, and placenta. Several multispecific OATs (OAT1-3, OAT-K1 and OATK2) and OATPs (organic anion transporting polypeptides; oatp1-3, LST-1, and PGT), have been cloned and characterized from various tissues. OATPs family of proteins share significant sequence homology, and general secondary protein structure (up to 12 transmembrane domains with cytoplasmic N- and C-terminus). Oatp3 (670 aa; 12 TM), cloned from rat retina, shares ~80-83% identity with oatp1-2 and ~77% to rat OAT-K1. Oatp3 is highly expressed in the kidney, and moderately in the retina. Oatp3 mediates uptake of taurocholate, thyroxine, and triiodothyronine. Most of the T4 secreted from the thyroid is deiodinated in peripheral tissues. The liver and kidney are the major sites for the production of T3 and T4. Therefore, oatp3 may play a critical role in transporting thyroid hormones from the circulation to the deiodination sites in the kidney