The Rb (Phospho Ser249) Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to RB1. This antibody recognizes Human, Mouse, and Rat antigen. The Rb (Phospho Ser249) Polyclonal Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, Immunocytochemistry, and Immunofluorescence.
Description
RB transcriptional corepressor 1 (RB1), Homo sapiens. The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]