The Anti-CD89 [14A8 (14.1)], Rabbit IgG Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to FCAR. This antibody recognizes Human antigen. The Anti-CD89 [14A8 (14.1)], Rabbit IgG Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, Flow Cytometry, Immunoprecipitation, and Other.
Description
This antibody binds human CD89 with a dissociation constant of Kd= 6.8 X10-10M.The binding of this antibody to human CD89 was confirmed with ELISA. This antibody was also capable of recognizing human CD89 expressing cells like human PMNL cells by flow cytometry. This antibody is not capable of blocking binding of IgA to CD89. This antibody can used to immunoprecipitate soluble CD89 (US7192582). A bispecific antibody construct incorporating the variable regions of the anti-gp41 antibody F240 and the anti-CD89 (immunoglobulin A [IgA] receptor) antibody 14A8 was reported to promote destruction of HIV type 1 (HIV-1) by neutrophils (PMID: 18272577). A Fab-like bispecific antibody molecule or Bi-Fab antibody generated from F240scFv and 14A8scFv showed significant antiboy dependent cell-mediated viral inhibition (ADCVI) activity for multiple clade B and clade C isolates by arming the neutrophils to inhibit HIV infection (PMID: 27419146)