MyBioSource.com's TRPV5 Rabbit pAb is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunofluorescence, and Western Blot. The TRPV5 Rabbit pAb Antibody was generated using TRPV5 as the antigen and it reacts with Human, Mouse, and Rat.
Description
Constitutively active calcium selective cation channel thought to be involved in Ca2+ reabsorption in kidney and intestine (PubMed:11549322, PubMed:18768590). Required for normal Ca2+ reabsorption in the kidney distal convoluted tubules. The channel is activated by low internal calcium level and the current exhibits an inward rectification (PubMed:11549322, PubMed:18768590). A Ca2+-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating