KMT2A/MLL Antibody

Product Specs
ItemKMT2A/MLL Antibody - BSA Free
CompanyNovus Biologicals, a Bio-Techne Brand
Price $539.00Supplier Page View Company Product Page
Catalog NumberNB600-248
ImmunogenThe immunogen recognized by this antibody maps to a region between residues 720 and 780 of human myeloid/lymphoid or mixed-lineage leukemia 1 using the number given in Swiss-Prot entry Q03164 (GeneID 4297)
NCBI Gene AliasesTRX1, HRX, MLL1A, MLL, MLL1, CXXC7, HTRX, ALL1, HTRX1, ALL-1, WDSTS, GAS7
Concentration1.0 mg/ml
ReactivityHuman,Mouse
ApplicationsChemotaxis,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,RNA immunoprecipitation
FormatTris-Citrate/Phosphate (pH 7.0 - 8.0)
Conjugate/TagUnconjugated
HostRabbit
Quantity100 ul
TargetKMT2A/MLL
NCBI Full Gene Namelysine methyltransferase 2A
ClonalityPolyclonal
PurityImmunogen affinity purified
IsotypeIgG
Antibody TypePrimary Antibodies
Research AreaTranscription Factors and Regulators
StorageStore at 4C. Do not freeze

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Sizes Available: 100 ul

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Novus Biologicals, a Bio-Techne Brand

United States: 10771 E Easter Ave

Centennial, Colorado 80112

United States

Phone:
303-730-1950
888-506-6887

Email: novus@novusbio.com

Company Profile

Website: https://www.novusbio.com

(1) TRIM24 directs replicative stress responses to maintain ALT telomeres via chromatin signalingMolecular CellJuly 17, 2025Daein Kim, Ragini Bhargava, Shih-Chun Wang, Wei-Che Tseng, Doohyung Lee, Riya Patel, Sungtaek Oh, Ray W. Bowman, Baylee A. Smith, Minkyu Kim, et al.Sciences,"Cat#: A302-368A, RRID: AB_1907251" Anti-BRD9,Abcam,Cat#: ab137245 Anti-MLL1,Novus,"Cat#: NB600-248, RRID:AB_3193987" Anti-PBRM,Fortis Life Sciences,"Cat# A301-591, RRID:AB_1078808" Anti-SP100,Enzo

(2) Histone-methyltransferase KMT2D deficiency impairs the Fanconi anemia/BRCA pathway upon glycolytic inhibition in squamous cell carcinomaNature CommunicationsAugust 8, 2024Wei Liu, Hongchao Cao, Jing Wang, Areeg Elmusrati, Bing Han, Wei Chen, Ping Zhou, Xiyao Li, Stephen Keysar, Antonio Jimeno, et al.Scientific, 10215-1-AP, 1:1000), FANCL (Proteintech, 66639-1-Ig, 1:1000), KMT2A (Novus Biologicals, NB600-248, 1:1000), KMT2B (Cell Signaling Technology, 47097, 1:1000), KMT2C (Sigma-Aldrich, SAB1300082, 1:1000),

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(7) MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genomeBloodJanuary 1, 0001"Wang QF, Wu G, Mi S, He F, Wu J, Dong J, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, et al."

(8) Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genesMolecular and cellular biologyJanuary 1, 0001"Lee JH, Skalnik DG."

(9) Protein arginine-methyltransferase-dependent oncogenesisNature cell biologyJanuary 1, 0001"Cheung N, Chan LC, Thompson A, Cleary ML, So CW."

(10) Pygo2 associates with MLL2 histone methyltransferase and GCN5 histone acetyltransferase complexes to augment Wnt target gene expression and breast cancer stem-like cell expansionMolecular and cellular biologyJanuary 1, 0001"Chen J, Luo Q, Yuan Y, Huang X, Cai W, Li C, Wei T, Zhang L, Yang M, Liu Q, et al."

(11) Pregnancy-induced noncoding RNA (PINC) associates with polycomb repressive complex 2 and regulates mammary epithelial differentiationPLoS geneticsJanuary 1, 0001"Shore AN, Kabotyanski EB, Roarty K, Smith MA, Zhang Y, Creighton CJ, Dinger ME, Rosen JM."

(12) Transcriptional activation of the mixed lineage leukemia-p27Kip1 pathway by a somatostatin analogueClinical cancer research : an official journal of the American Association for Cancer ResearchJanuary 1, 0001"Horiguchi K, Yamada M, Satoh T, Hashimoto K, Hirato J, Tosaka M, Yamada S, Mori M."

(13) Identification and characterization of a novel human PP1 phosphatase complexThe Journal of biological chemistryJanuary 1, 0001"Lee JH, You J, Dobrota E, Skalnik DG."

(14) Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOFCellJanuary 1, 0001"Dou Y, Milne TA, Tackett AJ, Smith ER, Fukuda A, Wysocka J, Allis CD, Chait BT, Hess JL, Roeder RG."

(15) Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemiaPLoS geneticsJanuary 1, 0001"Akalin A, Garrett-Bakelman FE, Kormaksson M, Busuttil J, Zhang L, Khrebtukova I, Milne TA, Huang Y, Biswas D, Hess JL, et al."

(16) Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitorsProceedings of the National Academy of Sciences of the United States of AmericaJanuary 1, 0001"Milne TA, Hughes CM, Lloyd R, Yang Z, Rozenblatt-Rosen O, Dou Y, Schnepp RW, Krankel C, Livolsi VA, Gibbs D, et al."

(17) Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesisPLoS geneticsJanuary 1, 0001"Scacheri PC, Davis S, Odom DT, Crawford GE, Perkins S, Halawi MJ, Agarwal SK, Marx SJ, Spiegel AM, Meltzer PS, et al."

(18) Reduction of Hox gene expression by histone H1 depletionPloS oneJanuary 1, 0001"Zhang Y, Liu Z, Medrzycki M, Cao K, Fan Y."

(19) Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in DevelopmentCell reportsJanuary 1, 0001"Barrett NA, Malouf C, Kapeni C, Bacon WA, Giotopoulos G, Jacobsen SEW, Huntly BJ, Ottersbach K."

(20) Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promotersThe Journal of neuroscience : the official journal of the Society for NeuroscienceJanuary 1, 0001"Huang HS, Matevossian A, Whittle C, Kim SY, Schumacher A, Baker SP, Akbarian S."

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