Fig 1: Promoting STING secretion attenuated BJOE’s effects on cGAS-STING pathway-related factors in delayed diarrhea mice. STING agonist DMXAA was used to activate the cGAS-STING pathway. (a) mRNA expression levels of cGAS, STING, CXCL10, CCL5, and IFN-β measured by quantitative real-time PCR (n = 6). (b) Representative protein imprinted bands of cGAS, STING, p-TBK1, TBK1, p-IRF3, and IRF3. (c) Protein expression of cGAS, STING, p-TBK1, TBK1, p-IRF3, and IRF3 were measured by Western blot (n = 5). (d) BJOE suppressed aberrant activation of the cGAS-STING pathway. Data are expressed as mean ± SD. #P < 0.05, ##P < 0.01, compared with the normal group. *P < 0.05, **P < 0.01, compared with the model group. &P < 0.05, &&P < 0.01, compared with the BJOE group.