Description
Product Characteristics: CCYC antibody, Cell cycle checkpoint protein antibody, Cell cycle checkpoint protein RAD17 antibody, FLJ41520 antibody, HRAD 17 antibody, hRad17 antibody, R24L antibody, Rad 17 antibody, Rad 24 antibody, RAD1 (S. pombe) homolog antibody, RAD1 homolog antibody, RAD17 antibody, RAD17 homolog (S. pombe) antibody, RAD17 homolog antibody, Rad17 like protein antibody, RAD17, S. pombe, homolog of antibody, RAD17_HUMAN antibody, RAD17Sp antibody, Rad24 antibody, Rad24, mouse, homolog of antibody, Rad24, S. cerevisiae, homolog of antibody, RF C activator 1 homolog antibody, RF C/activator 1 homolog antibody, RF-C/activator 1 homolog antibody
Target Information: The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2008]