Description
Product Characteristics:
Synonyms: E3 ubiquitin-protein ligase RNF34:Caspase regulator CARP1:Caspases-8 and -10-associated RING finger protein 1 (CARP-1):FYVE-RING finger protein Momo:Human RING finger homologous to inhibitor of apoptosis protein (hRFI):RING finger protein 34:RING finger protein RIFF:RING-type E3 ubiquitin transferase RNF34:RNF34
Target Information: The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]