Description
Product Characteristics:
Aliases: CLL associated antigen KW 5 antibody, CLL-associated antigen KW-5 antibody, HSRNASEB antibody, RBM38 antibody, RBM38_HUMAN antibody, RNA binding motif protein 38 antibody, RNA binding protein 38 antibody, RNA binding region (RNP1, RRM) containing 1 antibody, RNA binding region containing protein 1 antibody, RNA-binding motif protein 38 antibody, RNA-binding protein 38 antibody, RNA-binding region-containing protein 1 antibody, RNPC1 antibody, SEB4 antibody, SEB4B antibody, SEB4D antibody, ssDNA binding protein SEB4 antibody, ssDNA-binding protein SEB4 antibody
Target Information: RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell- specific isoform of FGFR2 (By similarity). Plays a role in myogenic differentiation