Description
Product Characteristics: RNF111 antibody, E3 ubiquitin-protein ligase Arkadia antibody, EC 2.3.2.27 antibody, RING finger protein 111 antibody, hRNF111 antibody, RING-type E3 ubiquitin transferase Arkadia antibody
Target Information: The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]