Description
Product Characteristics:
Aliases: Regulator of G protein signalling 13 antibody, Regulator of G Protein Signalling 18 antibody, Regulator of G-protein signaling 18 antibody, RGS 18 antibody, RGS13 antibody, RGS18 antibody, RGS18_HUMAN antibody
Target Information: This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]