Description
Product Characteristics: Rabenosyn-5:110 kDa protein:FYVE finger-containing Rab5 effector protein rabenosyn-5:RAB effector RBSN:Zinc finger FYVE domain-containing protein 20:RBSN:ZFYVE20
Target Information: Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (By similarity)