Description
Product Characteristics:
Aliases: 358 kDa nucleoporin antibody, ANE1 antibody, E3 SUMO-protein ligase RanBP2 antibody, IIAE3 antibody, Nuclear pore complex protein Nup358 antibody, Nucleoporin 358 antibody, Nucleoporin Nup358 antibody, NUP358 antibody, p270 antibody, RAN binding protein 2 antibody, Ran-binding protein 2 antibody, RANBP2 antibody, RBP2_HUMAN antibody, Transformation related protein 2 antibody, TRP 1 antibody, TRP 2 antibody, TRP1 antibody, TRP2 antibody
Target Information: RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008]