Description
Product Characteristics:
Aliases: Acute myelogenous leukemia 1 translocation 1 cyclin D related antibody, Acute myelogenous leukemia 1 translocation 1 protein antibody, AML1 MTG8 antibody, AML1T1 antibody, CBFA2T1 antibody, CDR antibody, Core binding factor runt domain alpha subunit 2 translocated to 1 antibody, Core binding factor runt domain alpha subunit 2 translocated to 1 cyclin D related antibody, Cyclin D related antibody, Cyclin D related protein antibody, Cyclin-D-related protein antibody, Eight twenty one protein antibody, ETO antibody, ETO protein antibody, MGC2796 antibody, MTG 8 antibody, MTG 8b antibody, MTG8 antibody, MTG8 protein antibody, MTG8_HUMAN antibody, MTG8b antibody, Myeloid translocation gene on 8q22 antibody, Protein CBFA2T1 antibody, Protein ETO antibody, Protein MTG 8 antibody, Protein MTG8 antibody, Runt related transcription factor 1 translocated to 1 (cyclin D related) antibody, Runt related transcription factor 1 translocated to 1 antibody, Runt related transcription factor 1 translocated to 1 cyclin D related antibody, RUNX1 translocation partner 1 antibody, RUNX1T1 antibody, Zinc finger MYND domain containing protein 2 antibody, Zinc finger MYND domain-containing protein 2 antibody, ZMYND 2 antibody, ZMYND2 antibody
Target Information: This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8\,21)(q22\,q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]