Description
Product Characteristics:
Aliases: BRCA1/BRCA2 containing complex, subunit 5 antibody, BRCC 5 antibody, BRCC5 antibody, DNA repair protein RAD51 homolog 1 antibody, DNA repair protein rhp51 antibody, FANCR antibody, hRAD51 antibody, HsRAD51 antibody, HsT16930 antibody, MRMV2 antibody, Rad 51 antibody, RAD51 antibody, RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) antibody, RAD51 homolog A antibody, RAD51 homolog antibody, RAD51 recombinase antibody, RAD51, S. cerevisiae, homolog of antibody, RAD51_HUMAN antibody, RAD51A antibody, RECA antibody, RecA like protein antibody, RecA, E. coli, homolog of antibody, Recombination protein A antibody
Target Information: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]