Description
Product Characteristics:
Aliases: RNF139 antibody, TRC8 antibody, E3 ubiquitin-protein ligase RNF139 antibody, EC 2.3.2.27 antibody, RING finger protein 139 antibody, RING-type E3 ubiquitin transferase RNF139 antibody, Translocation in renal carcinoma on chromosome 8 protein antibody
Target Information: The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008]