Description
Product Characteristics:
Aliases: E3 ubiquitin-protein ligase RNF103 antibody, hKF-1 antibody, KF-1 antibody, RING finger protein 103 antibody, RN103_HUMAN antibody, RNF 103 antibody, Rnf103 antibody, ZFP 103 antibody, Zfp-103 antibody, Zinc Finger Protein 103 antibody, Zinc finger protein 103 homolog antibody, Zinc finger protein expressed in cerebellum antibody, Zinc finger protein homologous to Zfp103 in mouse antibody
Target Information: The protein encoded by this gene contains a RING-H2 finger, a motif known to be involved in protein-protein and protein-DNA interactions. This gene is highly expressed in normal cerebellum, but not in the cerebral cortex. The expression of the rat counterpart in the frontal cortex and hippocampus was shown to be induced by elctroconvulsive treatment (ECT) as well as chronic antidepressant treatment, suggesting that this gene may be a molecular target for ECT and antidepressants. The protein is a ubiquitin ligase that functions in the endoplasmic reticulum-associated degradation pathway. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream CHMP3 (charged multivesicular body protein 3) gene. [provided by RefSeq, Oct 2011]