Description
Product Characteristics:
Aliases: 95 kDa retinoblastoma associated protein antibody, 95 kDa retinoblastoma protein binding protein antibody, 95 kDa retinoblastoma-associated protein antibody, BRE 1B antibody, BRE1 B antibody, BRE1 E3 ubiquitin ligase homolog B antibody, BRE1-B antibody, BRE1B antibody, BRE1B_HUMAN antibody, DKFZp686K191 antibody, E3 ubiquitin protein ligase BRE1B antibody, E3 ubiquitin-protein ligase BRE1B antibody, KIAA0661 antibody, MGC13051 antibody, Rb associated protein antibody, RBP 95 antibody, RBP95 antibody, RING finger protein 40 antibody, Ring finger protein 40 E3 ubiquitin protein ligase antibody, RNF 40 antibody, Rnf40 antibody, STARING antibody
Target Information: The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]