Description
Product Characteristics:
Aliases: 2810024C04Rik antibody, DNA repair protein rad18 antibody, E3 ubiquitin-protein ligase RAD18 antibody, EC 6.3.2.- antibody, hHR 18 antibody, hHR18 antibody, hRAD 18 antibody, hRAD18 antibody, MGC156682 antibody, Postreplication repair E3 ubiquitin-protein ligase RAD18 antibody, Postreplication repair protein hRAD18p antibody, Postreplication repair protein RAD18 antibody, RAD 18 antibody, RAD18 antibody, RAD18 homolog (S. cerevisiae) antibody, RAD18 homolog antibody, RAD18 S. cerevisiae homolog antibody, RAD18 S. cerevisiae homolog of antibody, RAD18 transcript variant antibody, RAD18_HUMAN antibody, Rad18sc antibody, Radiation sensitivity protein 18 antibody, RING finger protein 73 antibody, RNF 73 antibody, RNF73 antibody, Structural maintenance of chromosomes protein 6 antibody, YCR066W antibody, YCR66W antibody
Target Information: The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]