Description
Product Characteristics:
Aliases: d TMP synthase antibody, EC 2.1.1.45 antibody, HsT422 antibody, MGC88736 antibody, OTTHUMP00000162195 antibody, Thymidylate synthase antibody, Thymidylate synthetase antibody, TMS antibody, TS antibody, TSase antibody, Tyms antibody, TYMS protein antibody, Tyms thymidylate synthetase antibody, TYSY_HUMAN antibody
Target Information: Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008]