Description
Product Characteristics:
Aliases: CKBBP 1 antibody, CKBBP1 antibody, CKII beta binding protein 1 antibody, CKII beta-binding protein 1 antibody, Rbx 2 antibody, Rbx2 antibody, RBX2_HUMAN antibody, Regulator of cullins 2 antibody, RING box protein 2 antibody, RING finger protein 7 antibody, RING-box protein 2 antibody, RNF 7 antibody, RNF7 antibody, ROC 2 antibody, ROC2 antibody, SAG antibody, Sensitive to apoptosis gene antibody, Sensitive to apoptosis gene protein antibody, Zinc RING finger protein SAG antibody
Target Information: The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]