Description
Product Characteristics:
Synonyms: E3 ubiquitin-protein ligase RAD18:Postreplication repair protein RAD18 (hHR18, hRAD18):RING finger protein 73:RING-type E3 ubiquitin transferase RAD18:RAD18:RNF73
Target Information: The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]