Description
Product Characteristics: Rasgrf1 antibody, Cdc25 antibody, Grf1 antibody, Ras-specific guanine nucleotide-releasing factor 1 antibody, Ras-GRF1 antibody, CDC25Mm antibody, Guanine nucleotide-releasing protein antibody, GNRP antibody, Ras-specific nucleotide exchange factor CDC25 antibody
Target Information: The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]