Description
Product Characteristics:
Aliases: C3HC4 type zinc finger protein antibody, E3 ubiquitin protein ligase RNF8 antibody, E3 ubiquitin-protein ligase RNF8 antibody, FLJ12013 antibody, KIAA0646 antibody, Ring finger protein (C3HC4 type) 8 antibody, RING finger protein 8 antibody, Ring finger protein 8, E3 ubiquitin protein ligase antibody, RNF 8 antibody, RNF8 antibody, RNF8_HUMAN antibody, UBC13/UEV interacting ring finger protein antibody
Target Information: The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]