Description
Product Characteristics:
Aliases: AA032313 antibody, DKFZP566B1346 antibody, Dorfin antibody, Double ring finger protein antibody, Double ring-finger protein antibody, E3 ubiquitin-protein ligase RNF19A antibody, p38 antibody, p38 protein antibody, Ring finger protein 19 antibody, RING finger protein 19A antibody, Ring IBR ring domain containing protein Dorfin antibody, RN19A_HUMAN antibody, RNF19 antibody, RNF19A antibody, Ubce7ip2 antibody, UIP117 antibody, XYbp antibody
Target Information: The protein encoded by this gene contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquitin ligase that is localized in Lewy bodies, a characteristic neuronal inclusion in Parkinson's disease (PD) brains. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein binds and ubiquitylates synphilin 1 (SNCAIP) which is an interacting protein of alpha synuclein in neurons and a major component of Lewy bodies. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Feb 2012]