Description
Product Characteristics: Androgen receptor associated protein 54 antibody, Androgen receptor-associated protein 54 antibody, ARA 54 antibody, ARA54 antibody, E3 ubiquitin protein ligase RNF14 antibody, E3 ubiquitin-protein ligase RNF14 antibody, FLJ26004 antibody, HFB 30 antibody, HFB30 antibody, HRIHFB2038 antibody, RING finger protein 14 antibody, RNF 14 antibody, Rnf14 antibody, RNF14_HUMAN antibody, TRIAD 2 antibody, TRIAD2 antibody, Triad2 protein antibody
Target Information: The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]