Description
Product Characteristics:
Aliases: CARP 1 antibody, CARP-1 antibody, CARP1 antibody, Caspase regulator CARP1 antibody, Caspases-8 and -10-associated RING finger protein 1 antibody, E3 ubiquitin-protein ligase RNF34 antibody, FYVE-RING finger protein Momo antibody, hRFI antibody, Human RING finger homologous to inhibitor of apoptosis protein antibody, RFI antibody, RIF antibody, RIFF antibody, RING finger protein 34 antibody, RING finger protein RIFF antibody, RNF34 antibody, RNF34_HUMAN antibody
Target Information: The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]