Description
Product Characteristics:
Aliases: ATP dependent helicase RENT1 antibody, ATP-dependent helicase RENT1 antibody, Delta helicase antibody, FLJ43809 antibody, FLJ46894 antibody, HUPF 1 antibody, hUpf1 antibody, KIAA0221 antibody, Nonsense mRNA reducing factor 1 antibody, NORF 1 antibody, NORF1 antibody, pNORF 1 antibody, pNORF1 antibody, Regulator of nonsense transcripts 1 antibody, RENT 1 antibody, RENT1 antibody, RENT1_HUMAN antibody, Smg 2 antibody, Smg 2 homolog nonsense mediated mRNA decay factor antibody, UP Frameshift 1 antibody, Up frameshift mutation 1 homolog (S. cerevisiae) antibody, Up frameshift mutation 1 homolog antibody, Up frameshift suppressor 1 homolog antibody, Up-frameshift suppressor 1 homolog antibody, UPF 1 antibody, UPF 1 regulator of nonsense transcripts homolog antibody, upf1 antibody, UPF1 regulator of nonsense transcripts homolog antibody, UPF1 RNA helicase and ATPase antibody, Yeast Upf1p homolog antibody
Target Information: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. [provided by RefSeq, Jul 2008]