Fig 1: scRNA-seq analysis of glioblastomas reveals a large population of HAVCR2-expressing T cells. (A) A dot plot representing the mean expression of indicated genes and the percentage of macrophages, malignant cells, oligodendrocytes, and T cells expressing such genes in glioblastoma samples. (B) A t-distributed stochastic neighbor embedding (tSNE) plot of single cells identified in glioblastoma samples, as represented in (A), and colored according to cell type. tSNE plots for these cells are also presented and colored according to the mRNA levels quantified for (C) HAVCR2, (D) BAG6, (E) FOXO1, (F) IRF4, and (G) PRDM1. The dot plot and tSNE plots were generated using the Single Cell Portal (the Broad Institute of MIT and Harvard) by analyzing the scRNA-seq dataset published by Neftel et al. (2019) [29].