Fig 1: The significance of SIRT5 expression on DCM-related myocardial injury. (A) Strategy for SIRT5 KO mice. (B) Experimental procedure for mice. (C) Changes in FBG levels were assayed every 3 weeks. (D) Changes in body weight were assayed every 3 weeks. (E) M-mode echocardiogram of mice. (F) EF (%) and FS (%) of mice. (G) IVRT of mice. (H) Inflammatory infiltration in mouse myocardial tissues using HE staining. (I) Collagen deposition in myocardial tissues using Masson's staining. (J) The expression of SIRT1, SIRT3, SIRT4, SIRT5, and the Mal-Lys modification of the protein in mouse myocardial tissues using Western blot. All data are expressed as means ± SD (n = 10). *p < 0.05 vs. control group; #p < 0.05 vs. DCM (WT) group. Continuous data were compared by one-way/two-way ANOVA.