Fig 1: Simulation‐based evaluation of HLA‐Knockout. Number of allele‐specific sgRNAs identified for single‐allele knockout of HLA‐A, HLA‐B, HLA‐C, any HLA single Class I allele, double‐allele knockout (pan‐knockout) of HLA‐A, HLA‐B, HLA‐C or any HLA Class I gene based on 432 cell lines from the TCLP database. Pie charts indicate the proportion of PAM‐based and mismatch‐based guide sequences from the total number of guide sequences identified per category.