Phospho-c-Abl (Tyr245) (73E5) Rabbit mAb 2868S from Cell Signaling Technology

Product Specs
ItemPhospho-c-Abl (Tyr245) (73E5) Rabbit mAb
CompanyCell Signaling Technology
Price $401.00 Inquire
Catalog Number2868S
Quantity100 µl
ApplicationsW
ReactivityH
TargetAbl1 (Tyr226) phosphate
ModificationsAbl1 (Tyr226) phosphate
HostRabbit
NCBI Gene AliasesABL, BCR-ABL, CHDSKM, JTK7, bcr/abl, c-ABL, c-ABL1, p150, v-abl
ClonalityMonoclonal
NCBI Full Gene NameABL proto-oncogene 1, non-receptor tyrosine kinase
Research AreaMAP Kinase Signaling
Clone7300000
Molecular Weight135 (c-Abl); 210 (Bcr-Abl)

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) Preclinical studies and transcriptome analysis in a model of Parkinson’s disease with dopaminergic ZNF746 expressionMolecular NeurodegenerationFebruary 28, 2025Ji Hun Kim, Sumin Yang, Hyojung Kim, Dang-Khoa Vo, Han-Joo Maeng, Areum Jo, Joo-Heon Shin, Joo-Ho Shin, Hyeon-Man Baek, Gum Hwa Lee, et al.24543–1-AP, 1:5000), phosphorylated PARIS [12], phosphorylated c-Abl (Cell Signaling Technology; catalog no. 2868, 1:5000), tyrosine hydroxylase (Novus Biologicals; catalog no. NB300-109, 1:1000), SDHA (Cell Signaling Technology

(2) Non-Lactobacillus-Dominant and Polymicrobial Vaginal Microbiomes Are More Common in Younger South African Women and Predictive of Increased Risk of Human Immunodeficiency Virus AcquisitionClinical Infectious DiseasesApril 17, 2023Yiran Wang, Laura Noël-Romas, Michelle Perner, Samantha Knodel, Refilwe Molatlhegi, Sarah Hoger, Kenzie Birse, Christina Farr Zuend, Lyle R McKinnon, Adam D Burgeneralways/most times),1.23,(.56–2.71),.6083,1.34,(.56–3.26),.5115 No. of sexual partners,0.83,(.60–1.16),.2868,0.79,(.53–1.16),.2315 Sex acts in past 30 d,0.97,(.89–1.06),.5122,1.00,(.90–1.10),.9668 Adjusted

(3) Repurposing the Bis-Biguanide Alexidine in Combination with Tyrosine Kinase Inhibitors to Eliminate Leukemic Stem/Progenitor Cells in Chronic Myeloid LeukemiaCancersFebruary 3, 2023Muselli F, Mourgues L, Rochet N, Nebout M, Guerci A, Verhoeyen E, Krug A, Legros L, Peyron JF, Mary D.(F-8),sc-13119,SCB P-AMPK,P-AMPK (T172),2535,SCB PARP,PARP,9542 S,CST P-c Abl,P-c Abl (Y245) (73E5),2868 S,CST PTPMT1,PTPMT1,sc-390901,SCB P-STAT5,P-STAT5 (Tyr694) (C11C5),9359 S,CST STAT5,STAT5 (D2O6Y),94205,CST Antibodies

(4) Sidestream Smoke Extracts from Harm-Reduction and Conventional Camel Cigarettes Inhibit Osteogenic Differentiation via Oxidative Stress and Differential Activation of intrinsic Apoptotic PathwaysAntioxidants (Basel)December 15, 2022Nicole R. L. Sparks, Lauren M. Walker, Steven R. Sera, Joseph V. Madrid, Michael Hanna, Edward C. Dominguez, Nicole I. zur Nieden9 (Tyr153) (abcam ab79202), rabbit anti-c-Abl (CST 2862S), rabbit anti-phospho-c-Abl (Tyr245) (CST 2868S), rabbit anti-phospho-c-Abl (Tyr412) (CST 247C7S), rabbit anti-caspase 4 (ab22687) mouse anti-actin

(5) ABL kinases regulate translation in HER2+ cells through Y-box-binding protein 1 to facilitate colonization of the brainCell reportsAugust 30, 2022McKernan CM, Khatri A, Hannigan M, Child J, Chen Q, Mayro B, Snyder D, Nicchitta CV, Pendergast AM.(Cell Signaling #9744, 1:1000), GFP (Cell Signaling #2956, 1:2000–1:5000), phospho-ABL1 (Y245) (Cell Signaling #2868, 1:1000), Phospho-Tyrosine (Sigma #05–321, 1:1000), FLAG (Sigma #F1804,1:1000), Lamin B1 (Cell Signaling

(6) Self-Assembled Nanoparticles Based on Block-Copolymers of Poly(2-Deoxy-2-methacrylamido-d-glucose)/Poly(N-Vinyl Succinamic Acid) with Poly(O-Cholesteryl Methacrylate) for Delivery of Hydrophobic DrugsInternational Journal of Molecular SciencesOctober 24, 2021Mariia Levit, Alena Vdovchenko, Apollinariia Dzhuzha, Natalia Zashikhina, Elena Katernyuk, Alexey Gostev, Eugene Sivtsov, Antonina Lavrentieva, Tatiana Tennikova, Evgenia Korzhikova-Vlakh907 (O–Hδ); CONHR: 3300 (NHst), 1654 (C=Ost, «amide I»), and 1555 (NHδ, «amide II»); CH2: 2942 (νas), 2868 (νs), and 1435 (δ, CH2); CH3: 1382 (δs); RR’C=CR’’H: 820 (δCH); R’–COOR: 1181c (O–C–Cst as) and 1256

(7) Combination of PKCδ Inhibition with Conventional TKI Treatment to Target CML ModelsCancersApril 2, 2021Muselli F, Mourgues L, Morcos R, Rochet N, Nebout M, Guerci-Bresler A, Faller DV, William RM, Mhaidly R, Verhoeyen E, et al.-c Abl (Y245) (73E5) P-CRKL (Tyr207) P-STAT5 (Tyr694) (C11C5) PKCδ P-PKCδ (Thr505) STAT5 (D2O6Y) 9542 S 2868 S 3181 S CST Merck Millipore (Upstate) CST CST CST 9359 S CST 2058 S 9374S 94205 CST CST CST HSP90 P-STAT5 PKCδ P-KCδ STAT5 4.2.

(8) Nilotinib Improves Bioenergetic Profiling in Brain Astroglia in the 3xTg Mouse Model of Alzheimer’s DiseaseAging and diseaseApril 1, 2021Aida Adlimoghaddam, Gary G Odero, Gordon Glazner, R. Scott Turner, Benedict C AlbensiBioenergetic in AD Astroglia Cell signaling technology, Danvers, USA; 1:100), phospho-c-Abl (Tyr245) (2868, Cell signaling technology, Danvers, USA; 1:100), PGC-1α (PA5-38022, Thermo Fisher Scientific, Massachusetts,

(9) Nilotinib Improves Bioenergetic Profiling in Brain Astroglia in the 3xTg Mouse Model of Alzheimer’s DiseaseAging DisApril 1, 2021Aida Adlimoghaddam, Gary G Odero, Gordon Glazner, R. Scott Turner, Benedict C AlbensiCambridge, UK; 1:500), c-Abl (2862, Cell signaling technology, Danvers, USA; 1:100), phospho-c-Abl (Tyr245) (2868, Cell signaling technology, Danvers, USA; 1:100), PGC-1α (PA5-38022, Thermo Fisher Scientific, Massachusetts,

(10) NHD2-15, a novel antagonist of Growth Factor Receptor-Bound Protein-2 (GRB2), inhibits leukemic proliferationPLOS ONEAugust 11, 2020Tina R. Lewis et al.Inc., 3181S), and anti-phospho-c-ABL1 antibodies (dilution of 1:1000; Cell Signaling Technology Inc., 2868S). Anti-GAPDH antibodies (dilution of 1:15,000; Abcam, Ab181602) were used as a loading control. Goat

(11) Validation of a Drosophila model of wild-type and T315I mutated BCR-ABL1 in chronic myeloid leukemia: an effective platform for treatment screeningHaematologicaJanuary 1, 2020Outa AA, Abubaker D, Bazarbachi A, Sabban ME, Shirinian M, Nasr R.8% SDS-PAGE. Anti-ABL1 (SC-23, 1:1000, Santa Cruz Biotechnology, Santa Cruz, CA) and phospho-ABL1 (#2868, 1:500, Cell Signaling Technology) primary antibodies and anti-mouse (SC-2318, 1:5000, Santa Cruz Biotechnology,

(12) Targeting WEE1 to enhance conventional therapies for acute lymphoblastic leukemiaJournal of Hematology & OncologyDecember 1, 2018Andrea Ghelli Luserna Di Rorà et al.(#9525), CCNB1 (#4138), CDKN1A (#2947), pH2A.X (Ser139) (#2577S), MYT1 (#4282), p-c-ABL (Tyr245) (#2868), and Rad51 (#8875) from Cell Signaling. Antibody to CCNB2 (ab18250) was from Abcam. Antibody to β-actin

(13) Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiencyNature cell biologySeptember 1, 2017Giampazolias E, Zunino B, Dhayade S, Bock F, Cloix C, Cao K, Roca A, Lopez J, Ichim G, Proïcs E, et al.

(14) Discovery and characterization of a novel potent type II native and mutant BCR-ABL inhibitor (CHMFL-074) for Chronic Myeloid Leukemia (CML)OncotargetJuly 19, 2016Feiyang Liu et al.

(15) Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma modelsOncotargetJune 28, 2016Bullova P, Cougnoux A, Abunimer L, Kopacek J, Pastorekova S, Pacak K.

(16) JAK3 as an Emerging Target for Topical Treatment of Inflammatory Skin DiseasesPloS oneJanuary 1, 2016Alves de Medeiros AK, Speeckaert R, Desmet E, Van Gele M, De Schepper S, Lambert J.

(17) Functional Analyses of the Crohn's Disease Risk Gene LACC1PloS oneJanuary 1, 2016Assadi G, Vesterlund L, Bonfiglio F, Mazzurana L, Cordeddu L, Schepis D, Mjösberg J, Ruhrmann S, Fabbri A, Vukojevic V, et al.(4850), anti-EEA1 (3288), anti-fibrillarin (2639), anti-histoneH3 (4499), anti-LAMP1 (9091), anti-LC3B (2868), anti-NUP98 (2598), anti-PDI (2446), anti-Rab5 (3547) and anti-syntaxin-6 (2869) from Cell Signaling;

(18) The SH2 domain of Abl kinases regulates kinase autophosphorylation by controlling activation loop accessibilityNature CommunicationsDecember 23, 2014Allan Joaquim Lamontanara, Sandrine Georgeon, Giancarlo Tria, Dmitri I. Svergun, Oliver Hantschel(clone 4G10, Millipore, diluted 1:2,000 in Odyssey blocking buffer-PBS (Li-cor Biosciences)), pY245 (2868S, Cell Signaling, diluted 1:1,000 in Odyssey blocking buffer-PBS (Li-cor Biosciences)) or pY412 (2865S,

(19) Exposure of neuroblastoma cell lines to imatinib results in the upregulation of the CDK inhibitor p27(KIP1) as a consequence of c-Abl inhibitionBiochemical pharmacologyNovember 15, 2014Lupino E, Ramondetti C, Buccinnà B, Piccinini M.Santa Cruz Biotechnology (Heidelberg, Germany). Polyclonal antibodies to c-Abl (2862), phospho-c-Abl tyrosine (Tyr)-245 (2868) and phospho-pRb serine (Ser)-780 (3590) were from Cell Signaling (Rome, Italy). Polyclonal antibody

(20) Tyrosine kinase receptors as molecular targets in pheochromocytomas and paragangliomasModern pathology : an official journal of the United States and Canadian Academy of Pathology, IncAugust 1, 2014Cassol CA, Winer D, Liu W, Guo M, Ezzat S, Asa SL.

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Phospho-c-Abl (Tyr245) (73E5) Rabbit mAb

Phospho-c-Abl (Tyr245) (73E5) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

Citations (21)

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Phospho-c-Abl (Tyr245) (73E5) Rabbit mAb from Cell Signaling Technology

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