sAPP-Beta-Wild Type Anti-Human Rabbit IgG Affinity Purify 18957 from IBL- America

Product Specs
ItemsAPP-Beta-Wild Type Anti-Human Rabbit IgG Affinity Purify
CompanyIBL- America
Price $596.00Supplier Page View Company Product Page
Catalog Number18957
ApplicationsWB, IP
HostRabbit
ReactivityHuman
IsotypeIgG
Regulatory StatusFor research use only, not for use in diagnostic procedures
ClonalityPolyclonal
FormatLyophilized product from 1% BSA in PBS containing 0.05% NaN3
PurityPurified with antigen peptide
ImmunogenSynthetic peptide in portion of C-terminus of Human sAPPβ-Wild Type (ISEVKM)
StorageLyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C
Quantity100 ug

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IBL- America

8201 Central Ave NE Suite P

Minneapolis, Minnesota 55432

United States

Phone: 888-523-1246
763-780-2988

Company Profile

Website: http://www.ibl-america.com/

(1) Discovery of an APP-selective BACE1 inhibitor for Alzheimer's diseaseNeurotherapeuticsSeptember 1, 2025Jesus Campagna, Barbara Jagodzinska, Dongwook Wi, Chunni Zhu, Jessica Lee, Whitaker Cohn, Michael Jun, Chris Elias, Samar Padder, Olivier Descamps, et al.antibody from IBL catalog # 11088 biotinylated), and sAPPβ (Perkin Elmer AL276-acceptor + IBL catalog # 18957 biotinylated). For the assay, 2 μL of diluted or undiluted sample was added to a 384 well plate, followed

(2) Acute experimental colitis in 5xFAD Alzheimer''s disease mice leads to enhanced monocyte infiltration into the brain accompanied by reduced β-amyloid depositionAlzheimer's & dementia : the journal of the Alzheimer's AssociationJune 1, 2025Navalpur Shanmugam NK, Zamudio F, Vijaya Kumar DK, Barrett KA, VanDoren R, Chen M, Barr OM, Watson S, Lin CJ, Eimer WA, et al.#171610; 6E10, Biolegend catalog # 803012; BACE1, Cell Signaling catalog # 5606; sAPPβ, IBL, catalog # 18957; CD10, Santa Cruz Biotechnology, catalog # sc‐46656; IDE, abcam catalog # ab32216; F4/80, abcam, catalog

(3) The protective PLCγ2-P522R variant mitigates Alzheimer's disease-associated pathologies by enhancing beneficial microglial functionsJournal of neuroinflammationMarch 5, 2025Takalo M, Jeskanen H, Rolova T, Kervinen I, Hellén M, Heikkinen S, Koivisto H, Jokivarsi K, Müller SA, Koivumäki EM, et al.overnight at 4 °C: mouse anti-β-amyloid 1:1000 (6E10, #SIG-39320, BioLegend), rabbit anti-sAPPβ 1:100 (#18957, IBL America), mouse anti-APP N-terminal 1:1000 (22C11, #MAB348, Merck), rabbit anti-APP C-terminal

(4) Fatty‐acid amide hydrolase inhibition mitigates Alzheimer's disease progression in mouse models of amyloidosisThe FEBS JournalJanuary 16, 2025Sergio Oddi, Lucia Scipioni, Antonio Totaro, Giacomo Giacovazzo, Francesca Ciaramellano, Daniel Tortolani, Alessandro Leuti, Rita Businaro, Federica Armeli, Andras Bilkei‐Gorzo, et al.#PA1‐12529,1:1000 ADAM9,Rabbit,Cell Signaling #2099,1:200 sAPPα,Mouse,IBL #11088,1:200 sAPPβ,Rabbit,IBL #18957,1:200 APP,Mouse,Merck Millipore #MAB348,1:200 Iba1,Goat,Antibodies #A82670,1:2000 Aβ peptides,Rabbit,GenTex

(5) The Usnic Acid Analogue 4-FPBUA Enhances the Blood–Brain Barrier Function and Induces Autophagy in Alzheimer’s Disease Mouse ModelsACS Chemical NeuroscienceSeptember 4, 2024Sweilem B. Al Rihani, Khaled H. Elfakhri, Hassan Y. Ebrahim, Nour F. Al-Ghraiybah, Amer E. Alkhalifa, Khalid A. El Sayed, Amal KaddoumiGTX42033),WB,GeneTex sAPPα (cat# 11088),WB,"Immuno-Biological Laboratories (Minneapolis, MN)" sAPPβ (cat# 18957),WB,Immuno-Biological Laboratories "HRP-conjugated antigoat IgG, (cat# HAF109)",WB,"R&D Systems (Minneapolis,

(6) Long term administration of loquat leaves and their major component, ursolic acid, attenuated endogenous amyloid-β burden and memory impairmentScientific ReportsOctober 5, 2023Kensuke Iwasa, Sosuke Yagishita, Nan Yagishita-Kyo, Anzu Yamagishi, Shinji Yamamoto, Kota Yamashina, Chikara Haruta, Masashi Asai, Kei Maruyama, Kuniyoshi Shimizu, et al.antibodies were used: anti-mouse/rat APP (597) (28,055, IBL, Gunma, Japan), anti- human sAPPβ-Wild Type (#18957, IBL), anti-Tau5 (ab82579, Abcam, Cambridge, MA), anti-AT8 (ab75603, Abcam), anti-cAMP response element

(7) Tight control of the APP-Mint1 interaction in regulating amyloid productionBrain ResearchOctober 1, 2023Shawna M. Henry, Sabrina A. Kistler, Gavin D. Lagani, Christian R. O. Bartling, Dennis Özcelik, Vita Sereikaite, Kristian Strømgaard, Uwe Beffert, Angela HoAntibodies APP (N-terminus, EMD Millipore MAB348), APP (C-terminus, Sigma A8717), sAPPα (IBL 11088), sAPPβ (IBL 18957), APLP1 (T2263, Dr. Thomas Südhof), APLP2 (T2264, Dr. Thomas Südhof), GFP (Synaptic Systems 132002),

(8) APP and Bace1: Differential effect of cholesterol enrichment on processing and plasma membrane mobilityiScienceMay 19, 2023Claudia Capitini, Alessandra Bigi, Niccolò Parenti, Marco Emanuele, Niccolò Bianchi, Roberta Cascella, Cristina Cecchi, Laura Maggi, Francesco Annunziato, Francesco Saverio Pavone, et al.antibody conjugated to horseradish peroxidase. The primary antibodies were: Anti-Human sAPPβ-WildType (IBL 18957), Anti-Human sAPPα (IBL 11088), Anti-Human APP (C) (IBL 18961) and Anti-alpha Tubulin antibody (Abcam

(9) A tailored tetravalent peptide displays dual functions to inhibit amyloid β production and aggregationCommunications biologyApril 8, 2023Sato W, Watanabe-Takahashi M, Murata T, Utsunomiya-Tate N, Motoyama J, Anzai M, Ishihara S, Nishioka N, Uchiyama H, Togashi J, et al.Biolegend, Cat#800709), rabbit anti-sAPPβ antibody (1:50, Immuno-Biological Laboratories Co., Ltd., Cat# 18957), rabbit anti-EEA1 antibody (1:500, Thermo Fisher Scientific, Waltham, MA, USA, Cat# PA1-063A), rabbit

(10) Moringa Oleifera Alleviates AÎ² Burden and Improves Synaptic Plasticity and Cognitive Impairments in APP/PS1 MiceNutrientsOctober 14, 2022Yacoubou Abdoul Razak Mahaman, Jun Feng, Fang Huang, Maibouge Tanko Mahamane Salissou, Jianzhi Wang, Rong Liu, Bin Zhang, Honglian Li, Feiqi Zhu, Xiaochuan Wang(APP695, APP770, APP751)",pAb,Rabbit,Cell Signaling Technology (2452) Anti-APPβ,sAPPβ,pAb,Rabbit,IBL (18957) Anti-BACE1,BACE1 (D10E5),mAb,Rabbit,Cell Signaling Technology (5606) Anti-PS1,PS1,pAb,Rabbit,Cell Signaling Technology

(11) Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer's diseaseiScienceMarch 18, 2022Kaneshiro N, Komai M, Imaoka R, Ikeda A, Kamikubo Y, Saito T, Saido TC, Tomita T, Hashimoto T, Iwatsubo T, et al.,Immuno-Biological Laboratories,Cat#18711; RRID: AB_2341403 anti-human sAPPβ-wild type antibody,Immuno-Biological Laboratories,Cat# 18957; RRID: AB_1630824 normal rabbit IgG,Wako Pure Chemical Industries,Cat# 148-09551 normal mouse IgG,Santa Cruz

(12) EphA4 regulates Aβ production via BACE1 expression in neuronsFASEB journal : official publication of the Federation of American Societies for Experimental BiologyDecember 1, 2020Tamura K, Chiu YW, Shiohara A, Hori Y, Tomita T.APP (#18961, Immuno-Biological Laboratories, Gunma, Japan, 1:1000 dilution), anti-C terminus of sAPPβ (#18957, Immuno-Biological Laboratories, Gunma, Japan, 1:1000 dilution), anti-C-terminal domain of BACE1 (#18711,

(13) Codonopsis pilosula polysaccharide attenuates Aβ toxicity and cognitive defects in APP/PS1 miceAgingJuly 11, 2020Wan L, Zhang Q, Luo H, Xu Z, Huang S, Yang F, Liu Y, Mahaman YAR, Ke D, Wang Q, et al.USA" synaptophysin,amino acids 221-313 of SYP,17750,mAb,1:1000 for IF,Santa Cruz Biotechnology APPβ,Anti-human sAPPβ,18957,pAb,1:1000 for WB,IBL APP,Full length of total APP,2452S,pAb,1:1000 for WB,"Cell Signaling Danvers,

(14) Identification of calcium and integrin-binding protein 1 as a novel regulator of production of amyloid β peptide using CRISPR/Cas9-based screening systemFASEB journal : official publication of the Federation of American Societies for Experimental BiologyJune 1, 2020Chiu YW, Hori Y, Ebinuma I, Sato H, Hara N, Ikeuchi T, Tomita T.Immuno-Biological Laboratories, Fujioka-Shi, Gunma, Japan, 1:1,000 dilution), anti-C-terminally sAPPβ (#18957, ImmunoBiological Laboratories, Fujioka-Shi, Gunma, Japan, 1:1000 dilution), anti-C-terminally BACE1

(15) Chronic Periodontitis and Alzheimer Disease: A Putative Link of Serum Proteins Identification by 2D-DIGE ProteomicsFrontiers in aging neuroscienceJanuary 1, 2020Rong X, Xiang L, Li Y, Yang H, Chen W, Li L, Liang D, Zhou X.(Santa Cruz, sc-515353), anti-APP (Cell Signal Technology, 29765), AntisAPPα (IBL, 11088), Anti-sAPPβ (IBL, 18957) Anti-BACE1 (Abcam, ab2077), anti-ADAM10 (Cell Signal Technology, 14194) and anti-β-actin (Cell Signal

(16) Effect of Caffeine and Other Methylxanthines on Aβ-Homeostasis in SH-SY5Y CellsBiomoleculesNovember 2, 2019Daniel Janitschke, Christopher Nelke, Anna Andrea Lauer, Liesa Regner, Jakob Winkler, Andrea Thiel, Heike Sabine Grimm, Tobias Hartmann, Marcus Otto Walter GrimmBillerica, MA, USA), anti-ADAM10 735-749 Rabbit pAb (1:2000; Merck, Darmstadt, Germany), anti-Human sAPPβ 18957 (1:50; IBL America, Minneapolis, MN, USA), anti-rabbit IgG HRP Conjugate W401B (1:5000; Promega, Mannheim,

(17) Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 TranscriptionCellAugust 22, 2019Suh J, Romano DM, Nitschke L, Herrick SP, DiMarzio BA, Dzhala V, Bae JS, Oram MK, Zheng Y, Hooli B, et al.(76/8, NeuroMab), ADAM10 (422751, Millipore; ab124695, Abcam), mouse sAPPα (826801, Biolegend), sAPPβ (18957, IBL), sAPPβ-swe (10321, IBL), total sAPP (22C11, Millipore), BACE1 (D10E5, Cell Signaling; ab2077,

(18) Oleocanthal-Rich Extra-Virgin Olive Oil Restores the Blood-Brain Barrier Function through NLRP3 Inflammasome Inhibition Simultaneously with Autophagy Induction in TgSwDI MiceACS chemical neuroscienceAugust 21, 2019Al Rihani SB, Darakjian LI, Kaddoumi A.GTX42033),WB,GeneTex sAPPα (cat. no. 11088),WB,"Immuno-Biological Laboratories (Minneapolis, MN)" sAPPβ (cat. no. 18957),WB,Immuno-BiologicalLaboratories NLRP3 (cat. no. NBP212446SS),WB,"Novus Biologicals (Centennial, CO)" anti-goat

(19) The metalloprotease ADAMTS4 generates N-truncated Aβ4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's diseaseActa neuropathologicaFebruary 1, 2019Walter S, Jumpertz T, Hüttenrauch M, Ogorek I, Gerber H, Storck SE, Zampar S, Dimitrov M, Lehmann S, Lepka K, et al.recognizing the C-terminal neoepitope generated by β-secretase cleavage of wild-type APP, 1:50, IBL Cat. No. 18957); anti-APP (rabbit pAb raised against residues 756–770 of rat APP, 1:500, Synaptic Systems Cat. No.

(20) CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavageNature communicationsJanuary 3, 2019Sun J, Carlson-Stevermer J, Das U, Shen M, Delenclos M, Snead AM, Koo SY, Wang L, Qiao D, Loi J, et al.BioLegend), APP M3.2 (805701; BioLegend), APP 2E9 (MABN2295; Millipore), APP CT20 (171610; Millipore), sAPPβ (18957; IBL), BACE-1 (MAB931; R&D), GAPDH (MA5-15738, ThermoFisher), GFP (ab290, Abcam), GFP (A10262, Invitrogen),

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sAPP-Beta-Wild Type Anti-Human Rabbit IgG Affinity Purify from IBL- America

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IBL- America

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sAPP-Beta-Wild Type Anti-Human Rabbit IgG Affinity Purify from IBL- America

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