DFNA5/GSDME Rabbit pAb (APR27384N) from Leading Biology

Product Specs
ItemDFNA5/GSDME Rabbit pAb (APR27384N)
CompanyLeading Biology
Price $271.00Get Pricing Get Quote for this Product
Catalog NumberAPR27384N
ValidationWB (Homo sapiens)
Research AreaInflammasome Signaling Pathway
ApplicationsWB, IF, IHC
ReactivityHu, Ms, Rt
NCBI Gene AliasesDFNA5, ICERE-1
NCBI Full Gene Namegasdermin E
PurityAffinity purification
Quantity50 µl
HostRabbit
Conjugate/TagUnconjugated
TargetDFNA5/GSDME
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human DFNA5/GSDME (NP_004394.1)
IsotypeIgG
FormatPBS with 0.02% sodium azide, 50% glycerol, pH7.3
ClonalityPolyclonal

Questions and Answers

Can this antibody be used for detecting gasdermin E in mouse tissues?

Yes, the DFNA5/GSDME Rabbit pAb is reactive with mouse tissues, making it suitable for applications such as Western blotting, immunofluorescence, and immunohistochemistry in mouse models.

What applications is this antibody validated for, and how might it be useful in studying the inflammasome signaling pathway?

This antibody has been shown to work in Western blotting, immunofluorescence, and immunohistochemistry. It can be particularly useful in studying the inflammasome signaling pathway by allowing researchers to visualize and quantify gasdermin E expression and its role in pyroptosis and inflammation.

Is this antibody suitable for use in human samples, and what type of samples can I use it on?

Yes, the DFNA5/GSDME Rabbit pAb is reactive with human samples. It can be used on various sample types, including cell lysates and tissue sections, for applications such as Western blotting and immunohistochemistry.

What is the immunogen used for this antibody, and how does it relate to its specificity?

The immunogen for this antibody is a recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human DFNA5/GSDME. This specific immunogen contributes to the antibody's ability to selectively recognize gasdermin E in various species, including human, mouse, and rat.