Description
Product Characteristics:
Synonyms: RUNX2_HUMAN, Runt-related Transcription Factor 2, CBF alpha 1, CBF-alpha-1, PEBP2-alpha A, CBFA1, CCD, CCD1, Cleidocranial dysplasia 1, Core binding factor, Core binding factor runt domain alpha subunit 1, Core binding factor subunit alpha 1, MGC120023, Oncogene AML 3, OSF 2, OSF2, OSF-2, Osteoblast specific transcription factor 2, OTTHUMP00000016533, PEA2 alpha A, PEA2aA, PEBP2 alpha A, PEBP2A1, PEBP2A2, PEBP2aA1, Polyomavirus enhancer binding protein 2 alpha A subunit, Runt domain, Runt related transcription factor 2, SL3 3 enhancer factor 1 alpha A subunit, SL3/AKV core binding factor alpha A subunit, AML3, CLCD.
Target Information: This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2008]