Fig 1: TET3 interacting partners with roles in DNA replication and DNA repair(A) STRING analysis of TET3 interacting partners reveals a cluster with proteins involved in DNA binding, DNA helicase activity, and DNA repair.(B) STRING functional analysis of proteins from network shown in A identifies as most significant function DNA repair, whereas DNA repair complex and pre-replication complex and DNA strand elongation follow.(C) STRING analysis reveals cluster of proteins involved in DNA replication.(D) Key functions of proteins forming the cluster in C. The most significant function is pre-replicative complex DNA strand elongation. Among the identified functions was polymerase switching and epsilon DNA polymerase complex.(E) IP (left) of endogenous TET3 (+TET3) or IgG (+IgG) (negative control) from nuclear extracts of thymocytes in the presence of EtBr and benzonase followed by immunoblotting for TET3, MSH2, MCM2, and XRCC1. Note the presence of a specific band for each of the proteins exclusively in the +TET3 IP and not in the +IgG (negative control) IP. Total nuclear extracts, treated with EtBr and benzonase, were used as input (right). Note that TET3, MSH2, MCM2, and XRCC1 are detected by western blot in both samples. Histone 3 (H3) was used as loading control. One out of two representative experiments is shown.