Fig 2: Establishment of the animal model and detection of key gene expression.(A) Changes in the body weight of mice in each group; (B) representative maps of the colon tissue in each group; (C) disease activity index (DAI) of mice in each group; (D) representative diagram of H & E staining of the colon tissue of mice in each group; (E) relative expression levels of the key genes (ABCG2, IL1RN, REG4, SERPINB5 and TRIM29) (qRT-PCR); (compared with the NC group, *P < 0.05, **P < 0.01, ***P < 0.001).

Fig 3: Analysis and screening of key genes.(A) Venn diagram plotted for screening key genes; (B) protein interaction network diagram; (C) box plots of the expression of the five key genes (ABCG2, IL1RN, REG4, SERPINB5 and TRIM29) in the dataset; (D) ROC curves of the five key genes.

Fig 4: Expression verification of the key genes in GSE87466.(A) Expression box diagram of ABCG2; (B) expression box diagram of IL1RN; (C) expression box diagram of REG4; (D) expression box diagram of SERPINB5; (E) expression box diagram of TRIM29.