MyBioSource.com's Anti-GITR antibody (DM79), Rabbit mAb is a Rabbit monoclonal antibody. The Anti-GITR antibody (DM79), Rabbit mAb was generated using TNFRSF18 as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: EIA, Immunoassay, ELISA, and Flow Cytometry.
Description
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25 (+)CD4 (+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported