MyBioSource.com's Rabbit Anti-Pyruvate Kinase PKM Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Other. The Rabbit Anti-Pyruvate Kinase PKM Antibody was generated using PKM as the antigen and it reacts with Human.
Description
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival