MyBioSource.com's RPE65 Conjugated Antibody is a Rabbit monoclonal antibody. The RPE65 Conjugated Antibody was generated using retinoid isomerohydrolase RPE65, and RPE65 as the antigen. It reacts with Human, Mouse, and Rat. This antibody has been shown to work in applications such as: Other.
Description
The retinal pigment epithelium (RPE) is a monolayer simple epithelium in proximity to the outer surface of the retinal photoreceptor cells. Retinal pigment epithelium-specific protein (RPE65) is a 65kDa protein belonging to the beta-carotene dioxygenase family. This protein is important in 11-cis retinal production as well as in visual pigment regeneration. RPE65 is attached to the membrane by a lipid anchor when palmitoylated (membrane form) and soluble when unpalmitoylated. The soluble form of the protein binds vitamin A. Defects in RPE65 causes autosomal dominant retinitis pigmentosa and/or Leber congenital amaurosis type 2